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Current trials

Type 1 diabetes researchers are carrying out clinical research projects all around the world. They are reliant on people volunteering their time to help test ideas and make new discoveries. 

Researchers will work with people of different ages and backgrounds and sometimes they look for a specific medical history. They might even need people who do not even have type 1 diabetes. Follow the links below to learn about current trials that need volunteers.

MultiPepT1De: Slowing the progression of type 1 with peptide injections

What is the project trying to achieve? 

The research team, based at King's College London, is looking to slow the progression of type 1 diabetes by giving injections of small fragments (peptides) of the proteins found in the beta cells of the pancreas. They hope that this treatment will re-train the immune system so that it stops recognising beta cells as a target for destruction.

Who can take part? 

The King's team is looking for people who:

  • are aged between 18-45 years and
  • have been diagnosed with type 1 diabetes and received their first insulin injection less than 4 years ago

However, you can not take part if you:

  • are pregnant, breast feeding or planning a pregnancy
  • are not using adequate contraception (both males and females)
  • have used immunosuppressive or immunomodulatory therapies for 1 month prior to participation

More information

You can find out more about MultiPepT1De at their website, on Twitter or Facebook, or by contacting Dr Jake Powrie and the team directly on 020 7188 1929 or at [email protected]

Symptoms of depression in diabetes

What is the project trying to achieve? 

This team from the University of Liverpool is carrying out a research project to help understand more about perceptions of diabetes (type 1 and type 2) and depression. Specifically, they want to know how people with diabetes understand the nature of depression.

They are inviting anyone with either type 1 or type 2 diabetes to complete a set of questionnaires that ask about the nature of depression and about the beliefs people have about the causes of depression.

They anticipate that people will have different experiences of depression. It is possible that some people will currently have symptoms of depression, or have had symptoms of depression in the past, whereas others will never have experienced symptoms of depression.

They want to include people with different experiences so they can build a more complete picture of the nature of depression and the beliefs that people hold about the psychological aspects of depression. 

The invitation to take part in the study is open to anyone with diabetes, regardless of how they feel at the moment.

What is involved?

You will need to fill out five online questionnaires, which will take approximately 20 minutes, and agree to leave your contact details in order to be questioned again at a later date.

As the questions deal with depression, there is a small risk that you may find the subject matter distressing. However, you can choose not to take part at any point if you find this to be the case.

Who can take part? 

Adults with type 1 or type 2 diabetes can take part, whether they are experiencing symptoms of depression or not.

Contact details 

If you would like further information, you can contact Rebecca Purewal at [email protected] or on 07455 011718.

Your diabetes clinic study

What is the project trying to achieve? 

This study is trying to improve our understanding of why young adults attend, or don’t attend, their diabetes clinic. According to the researchers: "We are not yet sure what exactly makes a good clinic or what can make young people miss appointments, or stop going to the clinic altogether. We need to know more about your views of the diabetes clinic to be able to make important changes and improvements."

What is involved?

You will be asked to complete an online questionnaire, which will take about 20 minutes.

If you click on the link to the questionnaire, on the first page you will be asked to give your consent to take part in this study. In the questionnaire you will be asked to respond to questions about your diabetes, the things you do to take care of your diabetes, how you feel about having diabetes, how satisfied you are about the health service for diabetes care, and how often you go to appointments in the hospital.

Who can take part? 

Young adults with type 1 diabetes, aged between 18 and 30 years are invited to take part in this study.

Contact details 

If you would like further information, you can contact Lisa Hynes at [email protected] or on Twitter at @LisaHynes19, or fill out the contact form on the questionnaire website.

Studying the effect of lixisenatide in type 1 diabetes

What is the project trying to achieve? 

The study is testing a glucose-lowering drug called lixisenatide, which has already been licensed for use in type 2 diabetes. This study is looking to see how the same drug affects people with type 1 diabetes. 

What is involved?

The study is being run in Oxford and lasts approximately 4 months for each person. During the study each person will be asked to take study medication injections once a day for two sets of 4 weeks with a 4-week gap in-between. 

The investigators will also take blood samples to check the general health of volunteers and also to see if there have been any changes as a result of taking the study medication. 

Who can take part? 

The researchers are looking for people aged 18-65 years (inclusive) who have had type 1 for at least one year, and who are taking insulin to treat their diabetes. 

Where is the study being conducted? 

The study is taking place in the Clinical Research Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ. 

For more details please go to: http://www.ocdem.ox.ac.uk/clinical-research-unit 

Contact details 

If you would like further details or have any questions please contact [email protected] or telephone our research nurse Sarah White on 01865 857287.

Continuous glucose monitoring in women with type 1 diabetes in pregnancy trial (CONCEPTT)

What is the project trying to achieve? 

Poor glucose control during pregnancy can give rise to complications for both the mother and infant. For example, preeclampsia (high blood pressure and protein in the urine after the 20th week of pregnancy) and preterm birth are much more common in women with type 1, and the infants are at higher risk of developing type 2 diabetes and chronic illnesses as adults.

This international study, led by Canadian investigators, will test: 1) whether CGM use during pregnancy can improve glucose control and reduce the likelihood of complications and 2) whether CGM use in women planning pregnancy will improve glucose control to make pregnancy more likely, and as well as reducing the risk of complications. 

What are volunteers required to do?   

Eligible women will either use a CGM along with their standard insulin regimen, or continue on their standard insulin regimen without a CGM.

Who can take part? 

To be eligible to take part, you need to be a woman aged between 18 and 40 years, to have had type 1 for more than 12 months, and to be using either a pump or insulin injections (minimum 3 times a day). Those recruited to the group for pregnant women should have been pregnant for 13 weeks or less, and be carrying only one child (i.e. not twins). Those recruited to the pre-pregnancy group should be planning to become pregnant and looking to optimise their glucose control beforehand.

Where is the study being conducted? 

There are recruiting centres in the following locations:

  • Cambridge
  • Ipswich
  • Norwich
  • London
  • Southampton
  • Manchester
  • Sheffield
  • Middlesbrough
  • Leeds
  • Nottingham
  • Edinburgh
  • Glasgow
  • Aberdeen.

Contact details

Dr Helen Murphy
Addenbrooke's Hospital
Metabolic Research Laboratories
Level 4, Institute of Metabolic Science
Box 289

01223 769079
[email protected]

Estrogen in Type 1 Diabetes (EsTiD) study

What is the project trying to achieve?

Young people with type 1 tend to have lower blood levels of the hormone IGF-I than people who do not have diabetes. This is associated with difficulties in controlling blood sugar levels and it has been linked to the risk of developing complications.

Women who take the oral contraceptive pill have similar changes in their level of IGF-I as women with type 1. The pill contains two sorts of hormones but the effect on IGF-I is from oestrogen. Oestrogen seems only to affect IGF-I levels when it is taken by mouth, but not when it is made naturally by the body or when it is given as a patch. This study looks at the effect of estrogen from a tablet and a patch on IGF-I in young women with type 1.

Who can take part? 

The researchers are currently recruiting women aged between 16-35 who have had type 1 for over a year

Can interleukin-2 stop further damage to the pancreas in type 1 diabetes? (DILfrequency study)

What is the project trying to achieve?

This research study is investigating a new medication for type 1 diabetes: a drug called aldesleukin (interleukin-2).  The research team is investigating whether this can halt the damage to the pancreas of people with newly diagnosed type 1 diabetes and, if it can, how often it needs to be given, and in what dosage, to have the best effect.

Who can take part?

The team are currently recruiting people aged 18-70 who have been diagnosed with type 1 in the past five years.

Contact Details

For more details contact Dr Frank Waldron-Lynch and team at the University of Cambridge.

www.clinical-trials-type1-diabetes.com

Email: [email protected]

Tel: 01223 762327

Continuous glucose monitoring user survey

What is the project trying to achieve?

Professor John Pickup from King's College London, a pioneer in the development of insulin pump therapy, wants to hear about users' experiences with continuous glucose monitors (CGM).

Who can take part?

Anybody with type 1 diabetes who uses a CGM on a 24/7 basis (or almost) or their carers.

What are volunteers required to do?

Particpants can get involved by answering the questions in this survey  http://www.surveymonkey.com/s/B8TPZ9D

Contact Details

For more information email [email protected] 

Reducing with MetfOrmin Vascular Adverse Lesions in type 1 diabetes - REMOVAL

What is the project trying to achieve?

The trial is designed to test whether the drug metformin, when combined with insulin therapy, is effective in preventing or reducing the elevated risk of cardiovascular disease associated with diabetes.

What are volunteers required to do?

To be eligible for the REMOVAL study, you must be at least 40 years old, have T1D, and have either previously experienced a blood vessel complication or have risk factors for a blood vessel complications. If you decide to join the trial you will be asked to take a daily pill. This may be either metformin or a placebo. It is a three-year study, so you will have additional monitoring tests at your clinic visits while you are taking part in the study.

Where is the study being conducted?

The following hospitals in the UK are participating in the study:

  • Stobhill Hospital, Glasgow
  • Ninewells Hospital, Dundee
  • Diabetes Clinical Research Centre, Plymouth
  • Royal Devon and Exeter NHS Foundation Trust, Exeter
  • Royal Victoria Hospital, Newcastle
  • University Hospital of North Durham, Durham
  • Manchester Royal Infirmary, Manchester
  • Michael White Centre for Diabetes, Hull Royal Infirmary
  • University Hospital, Liverpool
  • International Centre for Circulatory Health, Imperial College Healthcare NHS Trust, London

Sites in the Netherlands, Denmark Canada and Australia are also recruiting patients to the study.

Contact details

For further details please visit: http://1.usa.gov/tSfXi0

Developing corneal confocal microscopy for human diabetic neuropathy

What is the project trying to achieve? 

This project is trying to develop a new automated and non-invasive eye test to assess for nerve damage in diabetic patients. At the moment this is assessed using relatively crude tests which miss early nerve damage and the more sensitive tests need to remove skin in the form of a biopsy to assess under a microscope. We are studying patients with Type 1 diabetes with short duration of diabetes (<10 yrs) but also patients with diabetes for over 50 years to try and assess which factors might protect these patients from developing major complications of diabetes as well as patients with impaired glucose tolerance who are yet to develop diabetes.

What are volunteers required to do?

We will undertake detailed testing of the nerves using the standard tests of neurophysiology, but in addition we will use our ophthalmic instrument called the corneal confocal microscope to try and see if the corneal test is as good if not better than the standard tests. The groups of patients we are studying include patients with Type 1 diabetes and in particular patients with diabetes for more than 50 years of diabetes. These patients will also have an assessment of proteins and metabolites in their blood and will undergo genetic assessment.

For further details please contact:

Professor R A Malik [email protected] Tel. 0161 275 1196

A longitudinal study of ophthalmic markers of neuropathy in Type 1 diabetes

What is the project trying to achieve?

This project is assessing the development and progression of neuropathy in patients with Type 1 diabetes. We are studying patients with Type 1 diabetes, Latent autoimmune diabetes of adults (LADA) and Type 1 diabetic patients with a >50 yrs of diabetes on an annual basis over 4 years.

What are volunteers required to do?

We will undertake detailed testing of the nerves using the standard tests of neurophysiology, but in addition we will use our ophthalmic instrument called the corneal confocal microscope to try and see if the corneal test is as good if not better than the standard tests.

For further details please contact 

Professor R A Malik [email protected] Tel. 0161 275 1196

Nephropathy Family Study (NFS) and Adolescent Type 1 Diabetes Cardio Renal Intervention trial (AdDIT)

What is the project trying to achieve? 

NFS aims to explore the link between protein in the urine of young people with diabetes (age 10 – 16 yrs) and blood pressure, blood fats and urinary protein in their parents.

AdDIT is a study looking at the effects of drugs which lower the blood pressure or blood fats.

What are volunteers required to do?

Volunteers are asked to provide two sets of urine samples to test for protein and at their annual clinic review they will be asked for some extra blood for checking HbAIc. Volunteers in NFS may be invited to join AdDIT or if they do not wish to do so they will be followed up in NFS.

Contact details

Screening is taking place in these regions of the UK:

Aylesbury and High Wycombe [email protected]
Birmingham [email protected]
Birmingham (Heartlands) [email protected]
Bristol [email protected]
Bolton [email protected]
Cambridge [email protected]
Ipswich [email protected]
Manchester [email protected]
[email protected]
Newcastle and 
Middlesborough
[email protected]
[email protected]
Northampton [email protected]
Norwich [email protected]
Oxford [email protected]
Reading [email protected]
Stockport

[email protected]

Wigan [email protected]
West Suffolk [email protected]

or email the coordinating centre: [email protected]

Type 1 Diabetes TrialNet

What is the project trying to achieve?

The goal of TrialNet in the UK is to perform intervention studies to preserve insulin-producing cells in individuals at risk for type 1 diabetes. TrialNet will focus on identifying individuals "at risk" for developing type 1 diabetes. Risk is based on having autoantibodies or other markers and results of certain tests. These tests include Oral and Intravenous Glucose Tolerance Tests.

TrialNet is screening relatives of people with type 1 diabetes to find out if these family members are "at risk" for developing type 1 diabetes.

What are volunteers required to do?

Screening involves a simple blood test to look for diabetes-related autoantibodies that may appear years before type 1 diabetes develops.  If the right combination of autoantibodies is present the participant may be eligible to continue into the intervention study (TrialNet Oral Insulin Study).

The intervention study requires a capsule containing crystalline insulin to be taken daily.  The participant needs to have clinic visits for fasting blood tests on a six monthly basis.

Participants who are ineligible for the intervention study but have autoantibodies present will be followed up on a 6 monthly basis in the TrialNet Natural History study.  If an alternative intervention study becomes available in TrialNet they will be offered a place on this (if eligible).

Research Nurses: Harriet Castleden, Ann Morgan

Contact details

TrialNet Team
Diabetes and Metabolism
Learning and Research
Southmead Hospital
Bristol BS10 5NB

Tel: 0117 323 8736/7
[email protected]

If none of these trials are suitable, you could ask your healthcare team about any research studies happening in your local area, or search the JDRF Type 1 Diabetes Clinical Trials Connection web portal, which lists type 1 diabetes trials worldwide – not just those funded by JDRF. The same is true of the US-based website clinicaltrials.gov.

In addition, the UK Clinical Research Network has a searchable database of UK trials for many medical conditions, including type 1 diabetes.