What is the study aiming to do?
The study explores if patches and tablets containing the hormone oestrogen change chemical signals that could help make blood glucose easier to control and reduce the risk of diabetes-related complications.
Who can take part?
The researchers are currently recruiting women aged between 16-35 who have had type 1 for over a year
Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D)
What is the study aiming to do?
This research study is investigating a new medication for type 1 diabetes, using a drug called aldesleukin (interleukin-2). The research team are investigating whether this medication can halt the damage to the pancreas of the people with newly diagnosed type 1 diabetes and if so, what dose of the drug is required for the best results.
Who can take part?
The team are currently recruiting people aged 18-50 who have been diagnosed with type 1 in the past two years.
Further Details
For more details contact Dr Frank Waldron-Lynch and team at the University of Cambridge.
www.clinical-trials-type1-diabetes.com
Email: DILT1D@cimr.cam.ac.uk
Tel: 01223 762327
Text: DILT1D to 82727
What is the study aiming to do?
This study is investigating the factors that might influence glycaemic control (the HBa1c test) in people living with type 1 diabetes who are between the ages of 16-25. This study aims to explore what might be going on in young people’s lives during this period, their experiences of clinical services, their understanding of their illness and how difficult they might have found being diagnosed with type 1 diabetes.
Who can take part?
The study is looking for volunteers aged between 16-25 who have type 1 diabetes.
What will participants be asked to do?
If you chose to take part in this study you will be asked to fill out an anonymous online questionnaire that should take no longer than 20 minutes to complete. You will also be asked for some demographic and clinical data such as your last HbA1c, hospital admissions, and clinical attendance. All information collected during the course of the research will be kept strictly confidential and anonymous and will only be used for the purpose of this study.
Contact Details
Claire Reidy, Postgraduate Researcher, Centre for Lifespan and Chronic Illness Research, University of Hertfordshire, College Lane, Hatfield, Hertfordshire AL10 9AB
Email: claire.reidy@rocketmail.com
What is the survey aiming to do?
Professor John Pickup from King's College London, a pioneer in the development of insulin pump therapy, wants to hear about users' experiences with continuous glucose monitors (CGM).
Who can take part?
Anybody with type 1 diabetes who uses a CGM on a 24/7 basis (or almost) or their carers.
What will participants be asked to do?
Particpants can get involved by answering the questions in this survey http://www.surveymonkey.com/s/B8TPZ9D
Contact Details
For more information email cgm2013uk@gmail.com
What is the study aiming to do?
Researchers are hoping to find out why exercise can be particularly difficult for people with diabetes and determine if regular exercise can help to protect the insulin-producing beta cells in people with Type 1 Diabetes. The benefits of protecting these cells is that insulin production will be preserved and glucose levels will improve. This is a 12 month long national study that is funded by the National Institute for Health Research (NIHR) Research for Patient Benefit programme. The study is called ‘What are the benefits of exercise in people with type 1 diabetes’, with the acronym EXTOD
Who can take part?
We are currently seeking people aged 16-60 who have been diagnosed with type 1 diabetes within the last 12 weeks.
What will participants be asked to do?
Participants will be randomly allocated into a control group (who will treat their type 1 as normal) and an exercise group who will be asked to undertake 150 minutes of moderate exercise a week. We will take over the diabetes care of the patient for the 1 year duration of the study.
Further details
More details can be obtained from www.uhb.nhs.uk/research-diabetes-extod.htm, or www.jcrubristol.org.uk/default.aspx.
Alternatively, contact Dr Amy Kennedy: 07765 867993 or extod@trials.bham.ac.uk.
What is this study aiming to do?
Eye charity, Fight for Sight are running an online survey for patients, carers and eye health professionals. They want to know what unanswered questions about the prevention, diagnosis and treatment of sight loss and eye disease these groups would like to see prioritised. They will use the results of this study to encourage researchers to investigate the topics that are most important to people with or at risk of eye disease.
Who can take part?
The study is open to people who have or are at risk of developing eye disease, their carers and eye health care professionals.
What will volunteers be asked to do?
Volunteers will be asked to complete a short online survey detailing the things the unanswered eye disease related questions they would like to see prioritised.
Contact details
For more details and to take the survey http://www.sightlosspsp.org.uk
What is the project trying to achieve?
This project is a clinical research study to investigate a new medicine for diabetic gastroparesis.Diabetic gastroparesis is a digestive problem associated with diabetes that prevents the stomachfrom emptying in a normal way. This often makes people feel full quickly when eating, feelexcessively full after a normal meal or feel bloated.
The study is testing an investigational medicine (a new medicine that is not approved forprescription by doctors) to make the stomach work normally and relieve the symptoms. It willmonitor the safety of the investigational drug and measure how well it works when compared toplacebo (an inactive substance).
Who can take part?
The study is looking for volunteers aged between 18-80 who have type 1 or type 2 diabetes and havebeen experiencing symptoms of gastroparesis for the last 3 months or more.
What will volunteer be asked to do?
The researchers will first perform tests to see if you qualify to take part in the study. Participants willthen be asked to make 7 regular trips to the research clinic over 6 weeks and take the investigationalmedicine as instructed by the study doctor. Participants will also be asked to record any changes intheir health that occur while they are taking the drug.
Contact Details
Study centres are in Cambridge, London and Salford. To find a local study site, contact:
Addenbrooke’s Centre for Clinical Investigation
Addenbrooke’s Hospital
Hill Rd
Cambridge
CB2 2GG
01223296005
http://volunteers.gsk.co.uk
What is the project trying to achieve?
The project is designed to hear the opinions of people with type1 diabetes and their families on the latest diabetes technologies. We are interested in what people with diabetes think about how our research will benefit them. Participants will not be asked to trial the artificial pancreas.
What are volunteers required to do?
Volunteers will be asked to attend 2 or 3 meetings a year to discuss new research projects. We would like to hear your opinions on matters such as the pros and cons of insulin pumps and glucose sensors, proposed research studies and ethical issues. Meeting will be informal with light refreshments provided.
Who can take part?
We are looking for a mixed group of people affected by type 1 diabetes. Parents and children, adolescents, adults and women with type 1 who have been pregnant are all welcome to join the group.
Where will the study take place?
The meetings will take place in Cambridge and travel expenses will be reimbursed.
Contact details
Mrs Josephine Hayes
Artificial Pancreas Project Coordinator
University of Cambridge
Institute of Metabolic Science
Addenbrooke's Hospital
Level 4, Box 289
Hills Road, Cambridge CB2 0QQ
Email: jfh31@cam.ac.uk
What is the project trying to achieve?
The trial is designed to test whether the drug metformin, when combined with insulin therapy, is effective in preventing or reducing the elevated risk of cardiovascular disease associated with diabetes.
What are volunteers required to do?
To be eligible for the REMOVAL study, you must be at least 40 years old, have T1D, and have either previously experienced a blood vessel complication or have risk factors for a blood vessel complications. If you decide to join the trial you will be asked to take a daily pill. This may be either metformin or a placebo. It is a three-year study, so you will have additional monitoring tests at your clinic visits while you are taking part in the study.
The following hospitals in the UK are participating in the study:
- Stobhill Hospital, Glasgow
- Ninewells Hospital, Dundee
- Diabetes Clinical Research Centre, Plymouth
- Royal Devon and Exeter NHS Foundation Trust, Exeter
- Royal Victoria Hospital, Newcastle
- University Hospital of North Durham, Durham
- Manchester Royal Infirmary, Manchester
- Michael White Centre for Diabetes, Hull Royal Infirmary
- University Hospital, Liverpool
- International Centre for Circulatory Health, Imperial College Healthcare NHS Trust, London
Sites in the Netherlands, Denmark Canada and Australia are also recruiting patients to the study.
For further details please visit: http://1.usa.gov/tSfXi0
What is the project trying to achieve?
This project is trying to develop a new automated and non-invasive eye test to assess for nerve damage in diabetic patients. At the moment this is assessed using relatively crude tests which miss early nerve damage and the more sensitive tests need to remove skin in the form of a biopsy to assess under a microscope. We are studying patients with Type 1 diabetes with short duration of diabetes (<10 yrs) but also patients with diabetes for over 50 years to try and assess which factors might protect these patients from developing major complications of diabetes as well as patients with impaired glucose tolerance who are yet to develop diabetes.
What are volunteers required to do?
We will undertake detailed testing of the nerves using the standard tests of neurophysiology, but in addition we will use our ophthalmic instrument called the corneal confocal microscope to try and see if the corneal test is as good if not better than the standard tests. The groups of patients we are studying include patients with Type 1 diabetes and in particular patients with diabetes for more than 50 years of diabetes. These patients will also have an assessment of proteins and metabolites in their blood and will undergo genetic assessment.
For further details please contact:
Professor R A Malik Rayaz.a.malik@man.ac.uk Tel. 0161 275 1196
What is the project trying to achieve?
This project is assessing the development and progression of neuropathy in patients with Type 1 diabetes. We are studying patients with Type 1 diabetes, Latent autoimmune diabetes of adults (LADA) and Type 1 diabetic patients with a >50 yrs of diabetes on an annual basis over 4 years.
What are volunteers required to do?
We will undertake detailed testing of the nerves using the standard tests of neurophysiology, but in addition we will use our ophthalmic instrument called the corneal confocal microscope to try and see if the corneal test is as good if not better than the standard tests.
For further details please contact
Professor R A Malik Rayaz.a.malik@man.ac.uk Tel. 0161 275 1196
What is the project trying to achieve?
NFS aims to explore the link between protein in the urine of young people with diabetes (age 10 – 16 yrs) and blood pressure, blood fats and urinary protein in their parents.
AdDIT is a study looking at the effects of drugs which lower the blood pressure or blood fats.
What are volunteers required to do?
Volunteers are asked to provide two sets of urine samples to test for protein and at their annual clinic review they will be asked for some extra blood for checking HbAIc. Volunteers in NFS may be invited to join AdDIT or if they do not wish to do so they will be followed up in NFS.
For further details please contact:
Screening is taking place in these regions of the UK:
or email the coordinating centre: ukgrid@paed.cam.ac.uk
What is project trying to achieve?
The goal of TrialNet in the UK is to perform intervention studies to preserve insulin-producing cells in individuals at risk for type 1 diabetes. TrialNet will focus on identifying individuals "at risk" for developing type 1 diabetes. Risk is based on having autoantibodies or other markers and results of certain tests. These tests include Oral and Intravenous Glucose Tolerance Tests.
TrialNet is screening relatives of people with type 1 diabetes to find out if these family members are "at risk" for developing type 1 diabetes.
What are volunteers required to do?
Screening involves a simple blood test to look for diabetes-related autoantibodies that may appear years before type 1 diabetes develops. If the right combination of autoantibodies is present the participant may be eligible to continue into the intervention study (TrialNet Oral Insulin Study).
The intervention study requires a capsule containing crystalline insulin to be taken daily. The participant needs to have clinic visits for fasting blood tests on a six monthly basis.
Participants who are ineligible for the intervention study but have autoantibodies present will be followed up on a 6 monthly basis in the TrialNet Natural History study. If an alternative intervention study becomes available in TrialNet they will be offered a place on this (if eligible).
Research Nurses: Harriet Castleden, Ann Morgan
Contact details:
TrialNet Team
Diabetes and Metabolism
Learning and Research
Southmead Hospital
Bristol BS10 5NB
Tel: 0117 323 8736/7
trialnet-uk@bristol.ac.uk
What is the project trying to achieve?
The aim of this international study is to test oral insulin to see if it could delay or prevent the onset of diabetes in children who are at very high risk of developing diabetes. Pre-Point is a pilot study to decide on the best dose to use for a larger, definitive trial.
What are volunteers required to do?
The study is open to children aged 18mths -7yrs who do not have Type 1 diabetes but have at least two 1st degree family members (parent(s) or sibling(s)) with Type 1 Diabetes or an identical twin with Type 1 diabetes.
Before study entry the child will be screened to check if they are eligible. This initially involves taking a mouth swab for DNA testing. If results show the child is in the high risk genetic group they will then be offered a blood test to check for pancreatic autoantibodies. If the autoantibodies result is negative, the child can be enrolled into the Pre-Point study. They will be asked to take oral insulin daily for 3 -18 months and attend clinic visits every 6 months. If the autoantibodies result is positive the child may be eligible for other prevention studies but this will be discussed with the parents at that time.
Contact details for finding out further info (website, email, telephone number)
Ann Morgan/Harriet Castleden
Tel: 0117 323 8736
Email: pre-point@bristol.ac.uk
www.diabetes-point.org
What is the project trying to achieve?
We are studying whether a new type of treatment that uses a fragment of a protein from the insulin making cells (proinsulin) can be used to stop the autoimmune process that destroys these cells in type 1 diabetes. The new approach is called “peptide immunotherapy” and has been termed a kind of “Diabetes Vaccine”. In this early phase study, we are mainly checking that the treatment is a safe. This is the second study with this treatment and the first study showed no significant side effects other than redness at the site of injection.
What are volunteers required to do?
Before entering the trial, we will do blood tests to check that you do have type 1 diabetes, that your body still makes some insulin, that you have the right type of immune system for this treatment and that you are healthy in all other ways. After entering the trial, you will have 12 treatments with a very small injection under the skin of your arm at 2 weekly intervals and then be followed up for a further 6 months (12 months in all). Overall there will be 15 visits to the research centre. After each treatment you will need to stay for about an hour for observations and during this time we will also give advice and help on blood sugar control and ask you to complete some questionnaires. There will also be three longer visits (3 hours) when we check the how much insulin your own body can make after drinking a build-up meal drink. The study visits can be timed for your convenience to some degree.
Who can take part?
You need to be aged between 18 and 40 years and have very recently been diagnosed with type 1 diabetes (the first treatment needs to be given within 100 days of the date of diagnosis).
Where is the study being conducted:
There will be study centres in Cardiff, Bristol, London (Guy’s Hospital) and Newcastle.
Contact details for finding out further info:
Julie Pell, Trials Coordinator, Centre for Endocrine and Diabetes Science, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN. PellJC@cardiff.ac.uk
What is the project trying to achieve?
Our research team is running a project based on the Triple P - Positive Parenting Program. The aim of this project is to explore whether a Triple P parenting program is relevant, useful and interesting to parents of children aged 11-17 years who have type 1 diabetes. Triple P is used worldwide to help families build on their own knowledge, skills, and confidence. It offers positive parenting advice and focuses on making small changes to achieve big differences. We want to see if this can be a helpful tool for diabetic families. The aim is to promote happy and healthy family life.
What are volunteers required to do?
Volunteers will be asked to complete a survey which will take approximately 30-45 minutes. Parents will be asked to provide demographic information and some information about their child’s type one diabetes. Parents will then be asked to complete some questionnaires about their child’s behaviour, their own emotions and family functioning. Following this a Triple P video clip, some written Triple P material and the Triple P chronic illness tip sheet will be presented. Parents will be asked to rate how relevant, useful and interesting they find the Triple P information. All volunteers will remain anonymous throughout the process.
Who can take part?
Parent (or primary caregiver) of a child aged 11-17 years with a diagnosis of Type 1 Diabetes
Where is the study being conducted?
The research will be conducted in The Division of Clinical Psychology at The University of Manchester.
Contact details
Sarah Woodhead: Division of Clinical Psychology, 2nd Floor Zochonis Building, University of Manchester, Brunswick St, Manchester, M13 9PL
Email: sarahlouise.woodhead@postgrad.manchester.ac.uk
Or visit website: www.diabetesandparenting.org.uk/survey
What is the project trying to achieve?
Maintaining good health in Type 1 diabetes requires following a complex diabetes management plan. Passing responsibility of diabetes care to an adolescent is an important developmental task. It is important therefore, to provide appropriate support that the adolescent, siblings, and parents can benefit from. Our research team is running a project based on the Triple P - Positive Parenting Program. Triple P is used worldwide to help families build on their own knowledge, skills, and confidence. It has been adapted for use with families of adolescents with a chronic illness. The aim is to enhance the young person’s development and promote happy family life. We want to see if the “Teen Triple P” and Chronic Illness resources can be a helpful tool for diabetic families.
What are volunteers required to do?
We will place parents in 1 of 2 groups: the “Triple-P” group or a “comparison” group.
Both groups: are asked to complete two sets of questionnaires. These are completed at the start and end of the programme.
Triple-P group: receive Triple P resources. There is helpful advice for general parent/child relations. It also looks at common themes in chronic illness. This includes prevention and coping advice for: reducing family stress; helping child/siblings cope; reducing anxiety; managing treatment routines.
Comparison group: have no contact from the research team or Triple-P resources during the project. This lets us compare groups and see if Triple-P has been helpful. After completion of the second set of questionnaires, all parents in the comparison group will be offered Triple-P.
Who can take part?
Parent (or primary caregiver) of a child aged 11-17 years with a diagnosis of type 1 diabetes.
Where is the study being conducted?
Participants will be recruited from across the UK and Ireland. Participants can use the Triple P resources and complete questionnaires in the comfort of their own home. The data from the study will be collected and then analysed at The University of Manchester.
Contact details
Dr Francesca Doherty: Division of Clinical Psychology, 2nd Floor Zochonis Building, University of Manchester, Brunswick St, Manchester, M13 9PL
Email: Francesca.Doherty@postgrad.manchester.ac.uk
Tel: 07531 181211
Or visit website: www.diabetesandparenting.org.uk/support